How to Use Your Holte Glutathione Pen

Dosage & Protocol

Each pack contains two 750mg L-Glutathione cartridges. At the recommended 75mg (0.3ml) dose, you will receive 20 doses per pack, which provides approximately a one-month supply when following the standard protocol.

Recommended Routine

The Loading Phase: Most individuals start with one dose daily for the first three days to rapidly elevate baseline levels.
The Maintenance Phase: After the loading phase, transition to one dose every alternate day to keep your cellular antioxidant levels stable.

Tailoring Your Regimen

Glutathione requirements are highly individual. Depending on your personal goals and lifestyle:

Some users prefer daily administration for intensive support.
Others achieve excellent results utilizing the pen 1–2 times per week.

Listen to your body and adjust your frequency accordingly, or consult your healthcare practitioner to tailor the protocol to your exact needs.

How to Use Your Hōlte Glutathione Pen®
This guide provides step-by-step instructions to safely and effectively use your Hōlte Glutathione Pen® for subcutaneous injections.

Please follow the steps carefully to ensure proper use. Wash your hands thoroughly before you begin.

1. Setting Up the Pen

Prepare the Pen and Cartridge. Remove the Holte Pen® and a Glutathione cartridge from their packaging.
Allow the Glutathione cartridge to rest at room temperature for 5–10 minutes.

2. Unscrew the Cartridge Holder

Take the lid off the pen to expose the clear cartridge holder.
Unscrew the clear cartridge holder from the base of the pen.
If the plunger is exposed, press it into the base of the pen with your finger.

3. Insert the Glutathione Cartridge

Take the Glutathione cartridge and insert it into the clear cartridge holder with the silver tip going in first.
Screw the clear cartridge holder (with the Glutathione cartridge inside) back onto the base of the pen firmly.

4. Prime the Pen

Twist the base of the pen until the dose meter is fully extended.
Push the dose meter back in and watch the plunger move up inside the cartridge holder.
Repeat this process until the plunger touches the bung at the bottom of the cartridge and you feel resistance.
Your pen is now prepped and ready for daily use. Continue with the steps below.

Administering your Glutathione subcutaneous injection

1. Attach the needle

Take a 5mm needle tip from the pack and gently but firmly screw it onto the end of the Hōlte Pen®.
Do not remove the needle tip cover yet.

2. Clean the injection site

Use an alcohol wipe to clean the injection site.
Choose a fatty area such as the abdomen (belly). Rotate the injection site each time to avoid skin damage or dimpling.

3. Set your dose

Dosage: 75mg - 0.3ml per dose (20 doses per kit).
Protocol: 1 x 0.3ml on alternate day. Listen to your body and adjust your frequency accordingly, or consult your healthcare practitioner.
Twist the base of the pen until the pointer lines up with your prescribed dose.
Remove both the outer and inner needle tip covers.
The Glutathione solution has a strength of 750mg per 3ml cartridge (250mg/ml).

4. Administer the Injection

Gently pinch the skin around the injection site, pulling it about 5mm away from the muscle.
Place the needle at the injection site and press the pen down to pierce the skin.
Press the button at the base of the pen to depress the plunger and administer the Glutathione.
Hold the pen steady and count down three seconds before removing the needle.

5. Dispose of the Needle

Carefully replace the outer needle tip cover.
Unscrew the needle tip with the cover on and dispose of it in the sharps bin provided.

6. Store the Pen

Replace the pen lid.
Store the Holte Pen® in the fridge (between 2–8°C / 35.6–46.4°F) to keep the Glutathione cartridge fresh.

Important Notes for Safe Use

Rotate injection sites to prevent skin damage or dimpling.
It is normal to experience the following after an injection:
A drop of Glutathione or blood on the skin.
A small bruise if the needle wasn’t kept steady.
A temporary red mark at the injection site. This will fade and is harmless. If concerned about visible marks, consider injecting in areas covered by clothing.
Use a fresh needle for each use.
Use Glutathione cartridges before their expiration date.
Keep cartridges refrigerated.

Confirmation of understanding

By using the Hōlte Pen®, you confirm the following:

You will administer Glutathione subcutaneously only, as instructed.
You understand the risks (e.g., allergic reaction, infection) and commit to following the instructions exactly.
You are competent to perform subcutaneous injections and will dispose of needles appropriately.
Hōlte is not responsible for any adverse effects caused by improper use or failure to follow the instructions.

Important: This product is not intended to diagnose, treat, or cure any condition. Always consult a healthcare professional before starting Glutathione injections. Use sterile technique to avoid contamination or infection.