NAD+ Explained: Benefits, Downsides, and Why Celebrities Are Talking About It

NAD+ (nicotinamide adenine dinucleotide) has become one of the most talked-about topics in the health and wellness world. From longevity researchers to Hollywood celebrities, more and more people are asking what NAD+ is, why it matters, and whether taking it daily can really make a difference.

To help you cut through the noise, we’ve taken the most popular questions people are searching for online and answered them here. Whether you’re considering NAD+ for personal wellness or exploring it as a therapy to offer in your clinic, this guide will give you a clear, balanced overview.

What happens if you take NAD+ every day?

One of the most common questions people have is: what would actually happen if you took NAD+ every day? The answer depends on how it’s delivered — NAD+ can be taken as oral supplements, IV infusions, nasal sprays, or transdermal applications.

On a cellular level, daily NAD+ supplementation is thought to support several critical functions:

• Energy production: NAD+ is a coenzyme in the Krebs cycle, helping turn food into usable energy (ATP). Higher NAD+ levels can mean more efficient energy metabolism.
• DNA repair: NAD+ is essential for enzymes called sirtuins and PARPs, which repair cellular damage and protect against aging.
• Brain health: NAD+ is linked to neurotransmitter balance and mitochondrial function, supporting focus and cognitive performance.
• Cell resilience: By maintaining mitochondrial health, NAD+ helps cells recover from stress, toxins, and everyday wear and tear.

People who take NAD+ daily often report benefits such as:

• Improved focus and concentration
• More stable energy throughout the day
• Better sleep quality
• Reduced feelings of fatigue
• Enhanced skin tone and vitality

That said, the exact impact varies from person to person. Some may feel changes within days, while others notice gradual improvements over weeks or months. Like many wellness approaches, consistency is key.

Does NAD+ actually work?

This is the million-dollar question — and the short answer is yes, but with nuance. NAD+ itself is not a “new invention.” It has been studied for decades and is a fundamental molecule found in every living cell. Without NAD+, life would not be possible, as it drives the chemical reactions that keep cells alive.

Research has shown that NAD+ levels decline as we age. In fact, by the time we reach middle age, our NAD+ levels may have dropped by as much as 50%. This decline is linked to fatigue, weaker DNA repair, slower metabolism, and increased risk of age-related conditions.

Increasing NAD+ availability in the body — whether through IV infusions, direct supplementation, or precursors like NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) — is believed to restore cellular energy and resilience.

Clinical evidence is growing:

• Animal studies show NAD+ supplementation can extend lifespan and improve metabolic function.
• Human studies suggest benefits in metabolic disorders, fatigue, and age-related decline.
• Clinics worldwide use NAD+ therapy for addiction recovery, chronic fatigue, and brain health support.

While NAD+ is not a miracle cure, there is solid science to support its role in energy, repair, and longevity. More large-scale clinical trials are needed, but early results are promising.

Does Jennifer Aniston take NAD+?

Celebrity wellness routines are always a hot topic, and Jennifer Aniston often comes up in searches around NAD+. 

In Hollywood and elite health circles, NAD+ has become part of the longevity and anti-aging movement. Stars, athletes, and executives use it for:

• Boosting recovery after demanding schedules
• Maintaining youthful energy and appearance
• Staying sharp under pressure

Whether it’s Jennifer Aniston, Madonna, or professional athletes, the buzz around NAD+ highlights its growing popularity. As more high-profile figures adopt wellness therapies, public interest follows.

What is the downside of NAD+?

While NAD+ is generally well tolerated, there are some potential downsides to be aware of. These depend on how the therapy is administered.

For IV infusions:

• Some people experience nausea, headaches, or stomach discomfort if the drip is administered too quickly.
• Temporary fatigue can occur after sessions, as the body adjusts to increased cellular activity.
• Infusions can be costly and require regular clinic visits.

For supplements:

• Most oral NAD+ or precursor supplements are well tolerated, though mild digestive issues may occur.
• The main downside is that bioavailability can vary — some products may not deliver enough NAD+ to make a noticeable difference.

Other considerations:

• The science is still emerging. While NAD+ plays a vital role in biology, not every claim made in marketing is fully backed by clinical evidence.
• Long-term effects of supplementation are still being studied.

Overall, the risks are low compared to many therapies, but cost, access, and individual response are the main factors to weigh.

What celebrities are using NAD+?

NAD+ is no longer a secret in elite wellness circles. Reports suggest that high-profile names — including Hailey Bieber, Jennifer Aniston, Gwyneth Paltrow, Kendall Jenner, Joe Rogan, and Madonna — have all reportedly used NAD+ therapies. Tony Robbins, the motivational speaker, has also spoken about his interest in NAD+ and its role in healthspan.

Here are some examples of how NAD+ has entered celebrity routines:

• Hailey Bieber famously said on Keeping Up with the Kardashians: “I’m going to NAD for the rest of my life and I’m never going to age.” (Allure)
• Jennifer Aniston is often named in wellness features as one of the stars linked with NAD+ IV drips for anti-aging benefits. (Vogue Arabia)
• Gwyneth Paltrow has featured NAD+ in her broader wellness programming. (The Osteo Center)
• Kendall Jenner is reported to have tried NAD+ infusions, often mentioned in beauty and health magazines. (Vogue Arabia)
• Joe Rogan has spoken publicly about NAD IV therapy on his podcast, citing benefits for energy, immune function, and mental clarity. (Liquid Mobile IV)
• Madonna is frequently mentioned in lifestyle outlets as a user of NAD+ drips for energy and recovery.
• Tony Robbins has endorsed NAD+ therapy in his discussions around biohacking and longevity.

Why the celebrity fascination? Simply put, NAD+ aligns with their needs:

• Fast recovery: Busy schedules and demanding performances require quick energy restoration.
• Longevity: For stars constantly in the public eye, maintaining vitality and youthfulness is a priority.
• Performance: Whether it’s on stage, in sports, or on screen, NAD+ is seen as a tool for peak performance.

The celebrity connection has helped NAD+ enter mainstream conversations. As media highlights its use among stars, interest among everyday people has surged.

What is Jennifer Aniston diagnosed with?

This question often appears alongside NAD+ searches, though it’s based on speculation. To date, there is no public diagnosis connecting Jennifer Aniston to NAD+ therapy. Instead, her name is linked to NAD+ because she is frequently associated with health, wellness, and longevity trends.

It’s worth remembering that many searches around celebrities are driven by curiosity, not confirmed fact. What matters more is the rising awareness of NAD+ as a potential tool for aging well and staying energetic.

So, should you try NAD+?

If you’re interested in supporting energy, recovery, and healthy aging, NAD+ may be worth exploring. The form you choose depends on your goals:

• Supplements: Easiest to take daily; ideal for ongoing support but poor absorption rates.
• IV drips: Fast, high-dose replenishment; best for noticeable short-term results.
• NAD+ Pens: A NAD-at-home solution which can be done quick and effectively without the price tag of an IV drip.
• Clinic therapies: Often combined with other treatments for holistic care.

Key Takeaways

• NAD+ is a vital molecule that declines with age, impacting energy and repair.
• Daily NAD+ use may support focus, recovery, and healthy aging.
• The therapy is backed by science, though more human trials are needed.
• Side effects are generally mild, with cost and accessibility being the main downsides.
• Celebrities including Hailey Bieber, Jennifer Aniston, Gwyneth Paltrow, Kendall Jenner, Joe Rogan, and Madonna are helping bring NAD+ into the spotlight.

Disclaimer: This article is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before starting any new supplement or therapy.

Find out more about Holte NAD+