How to Use the NAD+ Pen: A Beginner’s Guide

The Holte NAD+ Pen™ was designed to make cutting-edge wellness simple. For many first-time users, the idea of using a pen for subcutaneous delivery can feel unfamiliar—but rest assured, this process is easier than you might think. With the right steps and a little practice, you’ll feel confident, empowered, and ready to enjoy the benefits of NAD+ for energy, focus, and healthy ageing.

What is the NAD+ Pen?

The NAD+ Pen is an easy-to-use device that delivers nicotinamide adenine dinucleotide (NAD+) directly into your system through a quick, subcutaneous injection. This approach offers higher bioavailability compared to oral supplements, meaning your body can absorb more of what it needs. Many busy professionals and health-conscious early adopters prefer this method because it is fast, efficient, and discreet.

Why a Beginner’s Guide?

At Holte, we know starting something new can feel daunting. This comprehensive guide will walk you through every step—setup, usage, and even troubleshooting—so that you can get started with confidence. Our goal is to reduce any anxiety, answer common questions, and give you a routine that fits seamlessly into your lifestyle.

Step 1: Unboxing and Preparing Your Holte Pen

When you first open your Holte Pen, you’ll find:

• The reusable Holte Pen device
• NAD+ cartridge (refillable vial or pre-filled cartridge, depending on your order)
• Sterile needles for safe and clean use
• Quick-start instruction card

Before handling any part of the pen, wash your hands thoroughly with soap and water. This ensures a clean and hygienic setup.

Step 2: Loading the Cartridge

Next, you’ll insert the NAD+ cartridge into the pen:

1. Unscrew the pen body as shown in the instruction card.
2. Place the cartridge inside, with the rubber seal facing upward.
3. Screw the pen back together until secure.

You may need to prime the pen the first time you use a new cartridge—this simply means pressing the plunger until a small drop appears at the tip, ensuring the device is ready.

Step 3: Preparing the Injection Site

The NAD+ Pen is designed for subcutaneous injections, which means just beneath the skin, not into the muscle. Common sites include:

• Abdomen (at least 2 inches from the belly button)
• Thighs
• Back of the upper arm

Before injecting, clean the chosen area with an alcohol swab. This reduces the risk of irritation or infection.

Step 4: Injecting with Confidence

Here’s the easy part:

1. Attach a fresh needle to the tip of the pen.
2. Dial the recommended dosage.
3. Pinch a small fold of skin at the prepared site.
4. Insert the needle at a 45–90 degree angle (depending on your comfort and body type).
5. Press the plunger slowly and steadily until the full dose is delivered.
6. Withdraw the needle and apply gentle pressure with a clean cotton pad.

The entire process takes less than one minute and quickly becomes second nature.

Step 5: Aftercare and Storage

Once you’re finished:

• Safely dispose of the used needle in a sharps container.
• Store your Holte Pen with the cartridge attached in a cool, dry place.
• Keep spare cartridges refrigerated, and always check expiration dates.

Most users start with daily use, later adjusting to three to four times per week based on lifestyle and wellness goals.

Full details with videos can be found here

Common Questions

Does it hurt?

Most users describe the sensation as a quick pinch, similar to a light scratch. The needles are ultra-thin for maximum comfort.

How do I know I did it right?

If the plunger moves smoothly and you feel no leakage at the site, you’ve administered the dose correctly. Over time, this will feel completely natural.

What if I see a small bruise?

Minor redness or bruising can occasionally occur with subcutaneous injections—it’s harmless and typically resolves within a few days.

Troubleshooting the NAD+ Pen

Even with a simple device, questions may come up. Here are quick fixes to common issues:

• Pen not priming: Turn the dosage dial slightly higher and press firmly.
• Cartridge leaking: Ensure it is fully seated and the pen is screwed tight.
• Injection feels uncomfortable: Switch to a different site or adjust angle.
• Plunger stuck: Remove and reinsert the cartridge—sometimes a small air bubble is the culprit.

Making NAD+ Part of Your Routine

Think of your Holte Pen like your morning coffee or gym session—an act of self-care that pays long-term dividends. By integrating it into your regular schedule, whether before work, after a workout, or in the evening, you’ll find it becomes effortless.

Why the Holte NAD+ Pen is Different

Unlike other methods of supplementation, the Holte Pen is built for busy professionals and health-conscious early adopters. It combines science-backed bioavailability with sleek design and easy use. No lengthy clinic visits. No complicated processes. Just consistent, effective support for energy, focus, recovery, and healthy ageing.

Final Thoughts

Using the NAD+ Pen is simple, safe, and transformative once you’ve taken the first step. With this guide in hand, you’re ready to embrace the benefits of cellular wellness without hesitation.

Ready to start? Discover the Holte NAD+ Pen today and experience how easy wellness can be.