The Holte NAD+ Pen™ was built to simplify your wellness routine. But like all precision devices, it requires a refill from time to time. Switching cartridges might sound technical at first, but with the right steps it’s quick, safe, and effortless. This guide will show you how to change your NAD+ cartridge, care for your device, and make your regimen seamless.
Why Cartridge Refills Matter
Consistency is key when it comes to cellular health and energy. Missing a few doses can set back your progress. By knowing exactly how and when to switch cartridges, you’ll keep your Holte Pen ready to go, and avoid the frustration of running out at the wrong moment.
When to Replace Your Cartridge
Each cartridge contains a measured supply of NAD+. Depending on your usage, you’ll need to replace it after a certain number of injections. Signs it’s time to switch include:
- The plunger reaches the end of the cartridge
- You’re unable to prime the pen (and the cartridge is empty)
- You’ve reached the recommended usage limit for that cartridge
For most users, this means a new cartridge every 1–3 weeks.
Step-by-Step: How to Replace Your Cartridge
Follow these simple steps every time you change a cartridge:
1. Prepare Your Space
Wash your hands thoroughly and make sure your pen, new cartridge, and a clean surface are ready.
2. Remove the Old Cartridge
- Unscrew the body of the Holte Pen.
- Pull out the used cartridge carefully.
- If any liquid remains, dispose of the cartridge safely according to local guidelines.
3. Insert the New Cartridge
- Check the new cartridge’s seal and expiration date.
- Insert it into the pen with the rubber seal facing upward.
- Screw the pen body back together until secure, but don’t over tighten.
4. Prime the Pen
Turn the dosage dial slightly higher than normal and press the plunger until a small drop of liquid appears at the needle tip. Reset the dial to your recommended dose. This step ensures smooth delivery and removes air bubbles.
5. Ready for Use
Attach a fresh needle and continue with your normal routine. Your Holte Pen is now fully loaded and ready to deliver maximum bioavailability.
Storage and Handling Tips
- Opened cartridges: Keep your active cartridge stored in a refrigerator.
- Spare cartridges: Store in the fridge until use.
- Needles: Always use a new sterile needle for each injection.
- Sharps: Dispose of used needles in a sharps container, never regular bins.
Troubleshooting Cartridge Changes
“My new cartridge won’t prime”
Turn the dosage dial slightly higher and press again until liquid appears. If this doesn’t work, check that the cartridge is inserted correctly.
“I see a small leak”
Ensure the cartridge is fully seated and the pen body is snug but not overtightened.
“The plunger is stiff”
Remove and reinsert the cartridge. Sometimes air bubbles cause resistance.
How to Build a Refill Routine
The easiest way to stay consistent is to subscribe to Holte refills. You’ll receive cartridges on a schedule tailored to your usage, so you’re never left short. Many customers align their refills with weekly routines, like replacing a cartridge every Sunday evening, to keep things simple.
Final Thoughts
Switching cartridges in your NAD+ Pen should never feel stressful. With this step-by-step refill guide, you can handle the process with confidence and keep your wellness journey on track. Remember: it’s about making NAD+ support effortless, not overwhelming.
Stay stocked: Subscribe to Holte NAD+ refills and enjoy ongoing savings plus peace of mind that your next cartridge is always on hand.

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